High levels of AASs that mimic the body’s natural testosterone trigger, the hypothalamus, to shut down its production of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Without GnRH, the pituitary gland stops releasing luteinizing hormone (LH). LH normally travels from the pituitary via the blood stream to the testes, where it triggers the production and release of testosterone. Without LH, the testes shut down their production of testosterone.
In males, hCG helps restore and maintain testosterone production in the testes by mimicking LH and triggering the production and release of testosterone.
If hCG is used for too long and in too high a dose, the resulting rise in natural testosterone will eventually inhibit its own production via negative feedback on the hypothalamus and pituitary.
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