LGD-4033, also known as Ligandrol, is a SARM that has been shown to have positive effects on muscle building, body recomposition, sex drive, and bone density. Already in human trials, Ligandrol has been shown to be highly selective for muscle and bone cells, largely ignoring prostate or sebaceous cells. This makes the side effects for LGD-4033 minimal. LGD-4033 is a selective androgen receptor modulator (SARM). While it is currently being investigated as a pharmaceutical treatment for muscle wasting and weakness associated with aging, LGD-4033 has not been approved by the U.S. Food and Drug Administration (FDA) for clinical use in humans. According to a clinical trial conducted at the Boston Medical Center’s Section of Endocrinology, Ligandrol can help improve lean body mass and muscle strength. Another study conducted in January 2013 found that Ligandrol can help increase lean muscle mass, and was generally well tolerated by test subjects. Ligandrol is on the World Anti-Doping Association’s list of prohibited drugs and has been found in drug testing samples of some athletes.
In 2015, the quarterback of the Florida Gators, Will Grier, was suspended for testing positive for ligandrol, a claim that the University of Florida denies. In 2017, Joakim Noah was banned for twenty games by the NBA for testing positive for ligandrol. In 2019, Australian swimmer Shayna Jack tested positive for ligandrol. She denies knowingly taking the substance.
The Phase 2 clinical trial, initiated on 3 November 2016, consists of 120 patients recovering from hip fracture surgery. The randomized study participants will receive either a placebo or varying dose sizes of LGD-4033 over a period of 12 weeks, with improved lean body mass as the primary endpoint. Other endpoints include satisfactory results in terms of quality of life, safety, and pharmacokinetics.
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