Sermorelin is a 29 amino acid polypeptide that is used to treat growth problems (usually in children) due to growth hormone deficiency. It is the biologically active fragment of the human growth hormone-releasing factor (GHRH). It has a role as a diagnostic agent. It is a polypeptide and a peptide hormone. The biologically active fragment of the human growth hormone-releasing factor consists of GHRH(1-29)-amide. This N-terminal sequence is identical in several mammalian species, such as humans, pigs, and cattle. It is used to diagnose or treat patients with GROWTH HORMONE deficiency.
Clinical trials have revealed that sermorelin promotes changes in growth hormone levels that are similar to those of endogenous (inside the body) GHRH. In multiple studies, sermorelin has been shown to increase growth hormone levels, resulting in increased strength and stamina and better sleep.
Participants in clinical trials had a measurable increase in lean body mass and a decrease in body fat, most notably metabolically active and therefore dangerous abdominal fat.
Cognitive testing showed that participants had an increase in fluid intelligence scores, especially in problem-solving, psychomotor speed processing, and working memory.
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