Toremifene is used in postmenopausal women to treat breast cancer. It is usually used to treat cancer that needs estrogen, a female hormone, in order to grow (estrogen-receptor positive). Toremifene is a nonsteroidal antiestrogen that blocks the effects of estrogen in the breast tissue, thereby slowing or stopping the growth of cancer. Many breast cancer tumors will grow when estrogen is available in the body. This medicine blocks the effects of the estrogen hormone. As a result, the amount of estrogen that the tumor is exposed to is reduced, which will limit the growth of the tumor. The medication is a selective estrogen receptor modulator (SERM) and hence is a mixed agonist-antagonist of the estrogen receptor (ER), the biological target of estrogens like estradiol. It has estrogenic effects on bone, the liver, and the uterus and antiestrogenic effects on the breasts. It is a triphenylethylene derivative and is closely related to tamoxifen.
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