Welcome to the topic The Ultimate Guide to Trestolone Acetate?
In the event that you have come across the term “MENT” in one of the publications that you have read, there is no need for you to be perplexed about what it refers to or anything else of the kind because “MENT” is nothing more than an alternate name for “trestolone acetate.” In its whole form, MENT is referred to as 7-methyl-19-nortestosterone. Because this acetate is one of the powerful hormones that are still being manufactured in this day and age, it will continue to maintain its status as a powerful hormone. It is also useful for growing muscle; however, the acetate used for this purpose contains higher component concentrations than the acetate used for other purposes.
The Rise of MENT – Trestolone
Trestolone, also known as MENT (7alpha-methyl-19-nortestostrone), was one of numerous 19-nortestosterone derivatives that were explored as a prospective male contraceptive medication due to the distinctive chemical features that it possessed. Trestolone was also known as MENT. Because of progesterone’s capacity to inhibit the formation of new sperm, pharmaceutical companies initially tried to make an effective male contraceptive by mixing the hormone with testosterone.
This was done despite the fact that progesterone already existed. Although testosterone has been shown to reduce sperm production, the required amount for its use in a birth control method that just involves testing would be too high to avoid undesirable side effects. Testosterone can also be converted to DHT by the enzyme known as 5alpha-reductase; this conversion can have negative effects on the prostate and can hasten the progression of male pattern baldness. Because MENT is unable to bind to 5alpha-reductase and is unable to convert to DHT. It is an ideal choice for a male androgen contraceptive.
The one-of-a-kind alpha-methyl group that is located on carbon 7 of the molecule is responsible for this property. This methyl group protrudes out from below the steroidal ring structure, and its presence sterically prevents the conversion to DHT. Although it is a 19-nortestosterone derivative, MENT is still capable of aromatization and can engage in other tasks dependent on androgens. As a result, it can function in the body in a manner analogous to that of testosterone. Despite being a nandrolone derivative, MENT was shown to have a very low affinity for the progesterone and mineralocorticoid receptors. This was a surprising finding, given its structure.
It is also possible for the 7alpha-methyl group of MENT to inhibit the binding of MENT to sex hormone-binding globulin (SHBG). SHBG is a protein that binds with androgens (and estrogen), preventing them from binding to the androgen receptor. Another one of the 7alpha-methyl group’s distinctive qualities is that it can inhibit this binding. If you have ever had your testosterone levels checked, you are likely familiar with the reported values: total testosterone and free testosterone. The quantity of testosterone that is NOT coupled to SHBG is referred to as “free testosterone.” This type of testosterone is “free” to attach to the androgen receptor and cause its effects. Because MENT is incapable of binding to SHBG, it is effectively unrestricted in its ability to solely attach to the androgen receptor, where it can then produce the benefits associated with the usage of exogenous androgens.
Because of this, MENT is a very appealing choice for individuals who wish to not only develop great muscle but also maintain a high sex desire and avoid having unintended children while doing so. What conclusions can be drawn from the research on MENT? To tell the truth, it is fairly remarkable in its own right. In a study that was conducted in 1992 on rats to investigate the pharmacology of MENT, the researchers found that the anabolic potency of MENT was ten times greater than that of testosterone while also being 12 times more suppressive on HTPA. The National Institutes of Health conducted the study.
In light of this, if the typical male produces 4–7 mg of testosterone daily to maintain muscle growth and sexual function, then just 400–700 mcg of MENT is required to accomplish the same benefits. MENT acetate was employed in the same investigation to assess the rate of hydrolysis of the acetate ester as well as how rapidly increased MENT plasma levels were obtained. Both of these were determined using MENT acetate. The unesterified compound has a calculated half-life of only forty minutes, making it another extremely short-lived substance (not the acetate, which should extend the half-life slightly).
On male subjects, a very extensive human study was carried out in which a comparison was made between the effects of MENT and testosterone, both of which were accompanied by the progestin etonogestrel, on spermatogenesis, in addition to sex drive and safety biomarkers associated with the use of androgens. This was a comprehensive study that lasted for a total of 48 weeks and included testing on 29 participants. Participants were given either two-implant pellets, each containing 135 mg of MENT acetate with an estimated daily release of 400 mcg, or three implant pellets totaling 600 mg of testosterone, with one pellet administered every 12 weeks (both groups received 68mg of etonogestrel).
After 12 weeks of supplementation, sperm production was significantly reduced in both groups, with 80 percent of participants in both groups decreasing from an average of 55 x 106/mL to just 1 x 106/mL. The recovery period for the MENT group was 16 weeks, during which time the number of viable sperm grew to nearly 20 x 106/mL. In contrast, the testosterone group continued to have azoospermia until after 28 weeks had passed. LH and FSH levels were significantly repressed in both groups, with FSH decreasing 91 percent and LH dropping 90 percent in the MENT group.
This is relevant information on the safety of the treatment. After a period of 4 weeks, those in the MENT group experienced a decline in HDL levels of 14% and a rise in total triglyceride levels of 13%. Additionally, there was a considerable increase in systolic blood pressure in the MENT group, which subsequently reverted to normal levels after the completion of therapy. There were no significant increases in hematocrit or hemoglobin in the MENT group, which is unusual because increased hematocrit and hemoglobin levels are typically associated with increased androgenic levels.
The results of this study make it abundantly evident that MENT is a method of male contraception that is both safer and more effective than testosterone. The most important thing to take away from this study is that MENT appears to be somewhat safe for lipids and other biomarkers, but it unquestionably requires a PCT in order to return LH and FSH levels to normal levels. Because both MENT and this estrogen have the 7alpha methyl group, which does not attach to SHBG, it is reasonable to anticipate that this estrogen will be active and rapidly bind to the estrogen receptor, causing water retention and gynecomastia. This is because MENT also contains this group. When taking MENT, it is highly suggested that an aromatase inhibitor be used, such as Arimidex or letrozole. 
Potential side effects
After you have finished learning about all of the other aspects of a product, the side effects are likely the next thing that comes to mind for you. Trestolone acetate use is associated with a number of potential adverse effects, which we will now discuss with you. In general, you may experience a loss of hair or a thinning of the hair, an intensification of muscle cramps, acne, and hostility. Additionally, there is a possibility that your blood pressure will begin to rise at some point. So, this concludes everything that we were able to cover in this post on trestolone acetate. Before you move forward with this plan, we also hope you have some kind of assistance in relation to this subject.
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